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Bacteriology

Clostridioides difficile and anaerobic colitis

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SAMPLE QUESTION

Investigators give two groups of mice the same broad-spectrum antibiotic. After the drug has cleared, one group receives a washed intestinal bacterial community from untreated donors; the other receives sterile buffer. Both groups are then exposed to equal numbers of toxigenic C. difficile spores. The donor-community group has much less C. difficile growth and toxin in the colon. The two groups have similar epithelial integrity immediately before exposure.

Which mechanism best explains the protection provided by the donor community?