Phagocyte and adhesion defects
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A 6-week-old infant has an inflamed umbilical stump that remains attached and a culture-positive bacterial skin infection with very little pus. The absolute neutrophil count is 31,000/mm3. In a controlled flow chamber with activated healthy endothelium, the infant’s neutrophils make transient contacts but rarely remain attached long enough to cross the endothelial layer.