Autoimmunity, tolerance, and autoantibodies
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A mouse strain develops endocrine autoimmunity. Its medullary thymic epithelial cells express much less of several proteins normally made in peripheral endocrine organs. Investigators restore expression of one such protein only in the thymic epithelial cells, leaving its expression in the endocrine organ unchanged. Developing T cells with high-affinity receptors for a peptide from this protein can be tracked.