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General pathology and immunology

Cytokines and the inflammatory response

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SAMPLE QUESTION

Human endothelial cells are studied immediately after a selective block of new protein synthesis. Existing intracellular stores and surface proteins remain functional. One group is exposed to histamine for 2 minutes; another is exposed to TNF for 4 hours.

Compared with cells receiving the same stimuli without the block, which pattern is most likely?