Translation, protein targeting, and degradation
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A 9-year-old boy who has not received routine childhood immunizations is brought to the hospital after four days of sore throat, difficulty swallowing, and low-grade fever. An adherent gray membrane covers his tonsils and pharynx, and his neck is swollen. During hospitalization he develops an arrhythmia and reduced ventricular function. The bacterial toxin responsible for these findings inhibits protein synthesis in affected human cells.