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Biochemistry, cell biology, and genetics

Cell cycle checkpoints and mitosis

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SAMPLE QUESTION

A 27-year-old woman is diagnosed with breast cancer. She was treated for an osteosarcoma at age 13. Her father died of a soft-tissue sarcoma at age 38, and a paternal aunt developed a brain tumor in her thirties.

Loss of which normal cellular response most likely contributes to this family’s cancer predisposition?