Pentose Phosphate Pathway & G6PD Deficiency | USMLE Step 1
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A 19-year-old man develops jaundice and anemia during a febrile respiratory infection. His hemoglobin is 7.9 g/dL, reticulocyte count is 14%, and direct antiglobulin test is negative. The smear shows polychromasia and bite cells. A sample obtained before any transfusion has glucose-6-phosphate dehydrogenase activity of 10.2 U/g hemoglobin (laboratory reference interval, 8.0–11.9). He recalls a similar, self-limited illness after eating fava beans as a child.