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Biochemistry, cell biology, and genetics

Glycolysis & PFK-1 Regulation | USMLE Step 1

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SAMPLE QUESTION

A 64-year-old man undergoes positron emission tomography after CT shows a pulmonary mass. Images obtained after administration of fluorine-18 fluorodeoxyglucose show persistent tracer activity in the mass as activity in the blood decreases. The tracer enters cells through the same transporters used by glucose.

Which intracellular reaction most directly contributes to retaining the tracer in these cells?